US President Donald Trump launched the Genesis Mission on November 24, 2025, through an Executive Order directing the Department of Energy (DOE) to build a unified national platform for AI-driven scientific research. The order instructs the Secretary of Energy to oversee the mission “within DOE, consistent with the provisions of this order, including, as appropriate and authorised by law, setting priorities and ensuring that all DOE resources used for elements of the Mission are integrated into a secure, unified platform.” It also assigns the Assistant to the President for Science and Technology (APST) to coordinate the programme across federal departments and agencies.
The DOE states that the initiative “will transform American science and innovation through the power of artificial intelligence (AI), strengthening the nation’s technological leadership and global competitiveness.”
The mission will combine federal scientific datasets, high-performance computing at national laboratories, and partnerships with industry and academia to create an integrated AI system capable of training scientific foundation models, generating AI research agents, and accelerating discovery across disciplines.
According to the Department, the programme will target three challenge areas: enhancing American energy dominance, advancing discovery science, and supporting national security. Officials describe the effort as a modern national-scale science project anchored in DOE’s capabilities.
US Secretary of Energy Chris Wright said, “Throughout history, from the Manhattan Project to the Apollo mission, our nation’s brightest minds and industries have answered the call when their nation needed them.” He added that, under President Trump’s direction, the Genesis Mission will use the full capabilities of national laboratories, supercomputers, and data resources to position the United States as a leader in artificial intelligence and drive a new era of scientific progress.
The American Science And Security Platform
The Executive Order places the American Science and Security Platform at the centre of the Genesis Mission and directs the Secretary of Energy to build and manage it as a unified national research system. The Platform must bring together DOE supercomputers, advanced networking, and secure cloud-AI environments into a single integrated computing layer.
It must also provide AI-modelling frameworks, including agents that can explore design spaces, automate scientific workflows, and support iterative experimentation. Additionally, the Platform must deliver predictive models, simulation tools, design-optimisation systems, and domain-specific foundation models across the scientific fields the Mission prioritises.
The Order also lays out comprehensive requirements for data access. The Platform must provide secure access to proprietary, federally curated, open, and synthetic datasets, consistent with classification rules,…
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