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Allergic reactions to semen are, unfortunately, very real.

In an essay for The Conversation, reproductive science specialist Michael Carroll of the UK’s Manchester Metropolitan University explained that allergic reactions to seminal fluid can manifest as a nasty response to a partner’s ejaculate, or even your own.

The most common semen allergy is what’s known as “seminal plasma hypersensitivity” or SPH, in which women who have sex with men react to proteins in seminal plasma, the goopy stuff that makes up spunk. In other…


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Last Update: July 8, 2025